výuka metabolizmus železa eng

Created by Jiří Kofránek

Iron level regulation

Absorption and metabolism of iron

Iron bisglycinate

Iron metabolism

DMT1 and duodenal cytochrom reductase

Hem

Heme iron

Pool of Fe2+ iron

Fenton reaction

Ferritin

Hemosiderin

Iron transport

hephestin → Feroportin

Effect of hepcidin

Regulation of Hepcidin

Import of iron into cells from transferrin

Duodenal cell

Hepcidin regulatory pathways

Hepatocyte

Macrophage in the spleen

Iron metabolism

Intracellular local iron storage (local intracellular iron level control)

Intracellular iron level control (local control)

Intracellular iron level control by translation regulation (local control)

IRP/IRE translation regulation (mechanism of local control)

Pour but not owerflow! (systemic control by hepcidin)

Iron storage