Guyton's circulation model (1972)

Created by Jiří Kofránek

In 1972, Arthur C. Guyton, together with TGColeman and HJ Grander, published a fundamental article in the journal Annual Reviews of Physiology: Circulation: overall regulation, in which he described an extensive model of the physiological regulation of the circulatory system and its neuroendocrine regulation, including its connections to other subsystems of the organism - the kidneys , regulation of volume and electrolyte balance. The description of the equations was only in the form of a basic (but still fully illustrative) picture, the comments and justification of the formulations of these relations were very brief. The model was the first extensive model of the interconnected physiological functions of the organism and started the issue that is sometimes described today as integrative physiology. Later, A. Guyton's group further expanded this model and even provided those interested with listings of the model's programs in Fortran (most recently from 1986).