Combine 2024 lightning talk - Tomas Kulhanek

Created by Tomas Kulhanek

Modeling and simulation using industrial standards Modelica, FMI and web components.

!. some key features of modeling technologies

equation based

component based (modular, hierarchical, object oriented)

model of glucose insulin regulation

GI equation

components

supporting libraries

Physiolibrary & Chemical https://physiolibrary.org

Mateják, M. (2023, December). Creating cardiovascular and respiratory models using Physiolibrary 3.0. In Modelica Conferences (pp. 463-468).

hemodynamics of cardiovascular system

Ježek, F., Kulhánek, T., Kalecký, K., & Kofránek, J. (2017). Lumped models of the cardiovascular system of various complexity. Biocybernetics and Biomedical Engineering, 37(4), 666-678.

model of glucose insulin regulation - acausal form with components

2. why

Readability & Plausability

model of complex system may lead to implementation errors

A C Guyton, T G Coleman, H J Granger, Circulation: overall regulation, Annu Rev Physiol.1972;34:13-46.doi: 10.1146/annurev.ph.34.030172.000305.

Correction of schema after reimplementation in 2010

J.Kofránek, et al., Restoration of Guyton‘s Diagram for Regulation of the Circulation ...Physiol Res. 2010;59(6):897-908.doi: 10.33549/physiolres.931838.

Guyton's original scheme part of circulatory dynamics

equivalent implementation in component and acausal modeling language

Physiomodel

Complex model of physiology in Modelica based on HumMod and Physiolibrary

https://physiomodel.org

>60 000 equations

comprehensibility

Frank-Starling law is  much more visible in component model - "force of the heart muscle depends on pressure of incoming blood". 

standard for modeling -Modelica

Commercial tools:

Dymola,

, …

Open-source:

standard for simulation - FMI

Modelica tools support FMI

Matlab SIMULINK

PyFMI for Python

Bodylight.js for JS and web (model → FMI → emscripten → FMI JS with WebAssembly → + other components for charts, animation, markdown ...)

standard for exchange simulation setup - SSP

hemodynamics of cardiovascular system

blood-gas exchange

respiration

co-simulation of multiple models via FMI in static web app with bodylight.js

i

https://egolem.online/demo/

medical simulators for education

lecture supported by simulators

physiology and pathophysiology

web simulators in a browser / desktop/tablet

HTML, Markdown, web-components

hemodynamics

native mobile apps

control HW mannequin - simulation of patient on ECMO

OPC & REST API

bring virtual reality to life

WebGL+WebXR                           Unity+WebView

Conclusion

• consider to use industrial standards
• modeling 0D and 1D - Modelica, simulation - FMI (functional mockup interface), simulation setup and orchestration - SSP (system structure and parameterization)
• visualisation - web standards (HTML, WebAssembly, web components, WebGL, Canvas, Unity, ...)

links

models & libraries: https://www.physiolibrary.org

technology for simulation in web: https://bodylight.physiome.cz  (with source codes at GITHUB)

product demo: https://egolem.online

connect & colaborate

www.linkedin.com/in/tomaskulhanek/

acausal - do not dictate causality = rapid increase in reusability